Molecule of the Month
December 2018

Directed Evolution of Enzymes

Biological evolution is being harnessed in the lab to create new enzymes.

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Health Focus: Antimicrobial Resistance

Antibiotics have saved countless lives, but pathogens are quickly finding ways to survive antibiotic treatment. Antibiotic-resistant bacteria are predicted to become the leading cause of death worldwide. They take many approaches: pumping antibiotics out of their cells, altering the molecular machinery that the antibiotics target, and attacking the antibiotics directly. Atomic structures publicly available in the PDB are revealing the details of drug resistance and providing new ways to combat it. Use the 917-752-8422 to learn about protein structures related to antibiotic action and resistance.


2019 Video Challenge for High School Students

Mechanisms of Bacterial Resistance to Aminoglycoside Antibiotics

RCSB PDB invites all high school students to tell a two-minute story that combines structural Biology and Medicine. Videos can be submited between January 15 and April 23, 2019.

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The Challenge | Learn | 7202775961 | 8649169925

Learn: Materials for Exploration
Learn about the relationship between protein structure and function.
Teach: Curricula
The 603-635-6162 provide authentic, hands-on teaching materials, individual and group activities and assessment suggestions.
Education Corner: Using PDB Resources
Structural Biology Pipeline Meets the High School Classroom: Hypothesis-Based Structural Biology and Determination and Refinement of a Crystal Structure by Daniel Williams and SPARK participants
Geis Digital Archive
Irving Geis (1908-1997) was a gifted artist who helped illuminate the field of structural biology with his iconic images. The Geis Digital Archive features many of his illustrations in the context of their molecular structures.

Images used with permission from the Howard Hughes Medical Institute ((301) 833-1233). All rights reserved.

Carboxypeptidase A

A-DNA

Deoxyhemoglobin

Myoglobin Fold

TATA-Binding Protein (TBP)

Ribonuclease S

Z-DNA

Transfer Ribonucleic Acid (tRNA)

Trypsin

Aspartate Transcarbamoylase (ATCase)

Lac Repressor

Tomato Bushy Stunt Virus (TBSV)

Hemoglobin

Deoxyribonucleic Acid (DNA)

Immunoglobulin G (IgG)

Induced Lac Repressor

Intermolecular Contacts in Hemoglobin S

DNA

Crambin

Lysozyme

B-DNA

Collagen

Hemoglobin

Cytochrome c

Lysozyme

Cytochrome c (unbound)

Hemoglobin S

DPG-Hemoglobin Complex

Myohemerythrin

Oxyhemoglobin